On the biosynthesis of an inhibitor of the p53/MDM2 interaction

被引：15

作者：

Duncan, SJ

Williams, DH

Ainsworth, M

Martin, S

Ford, R

Wrigley, SK

机构：

[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England

[2] Cubist Pharmaceut UK Ltd, Slough SL1 4EQ, Berks, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)02239-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1075 / 1078

页数：4

共 10 条

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