On the biosynthesis of an inhibitor of the p53/MDM2 interaction

被引:15
作者
Duncan, SJ
Williams, DH
Ainsworth, M
Martin, S
Ford, R
Wrigley, SK
机构
[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England
[2] Cubist Pharmaceut UK Ltd, Slough SL1 4EQ, Berks, England
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0040-4039(01)02239-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1075 / 1078
页数:4
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