A recombinase diversified: new functions of the RAG proteins

被引：22

作者：

Brandt, VL ^{[1
]}

Roth, DB

机构：

[1] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(02)00325-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The RAG proteins were long thought to serve merely as a nuclease, initiating recombination by cleaving DNA. Recent work has shown, however, that these proteins are essential for many steps in the recombination pathway, such as opening hairpins and joining broken DNA ends, and that they can also act as a transposase, targeting distorted DNA structures such as hairpins.

引用

页码：224 / 229

页数：6

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