Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice

被引:56
作者
Adams, VC
Hunt, JRF
Martinelli, R
Palmer, R
Rook, GAW
Brunet, LR
机构
[1] SR Pharm, London WC1A 1DD, England
[2] UCL, Windeyer Inst Med Sci, Dept Med, London WC1E 6BT, England
关键词
M; vaccae; CD11c(+); regulatory T cells; pulmonary inflammation; hygiene hypothesis;
D O I
10.1002/eji.200324659
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The hygiene hypothesis proposes that common, harmless microorganisms, present throughout our evolutionary history, have helped to develop immunoregulatory mechanisms that prevent inappropriate immune responses by the host. Using a mouse model of allergic pulmonary inflammation, we report that treatment with an ubiquitous saprophytic mycobacterium, Mycobacterium vaccae, significantly reduces allergic inflammation by decreasing type 2 responses such as eosinophilia and IL-4 expression. Rather than observing an increase in type-1 cytokine expression, we found elevated production of IL-10 in the lungs suggesting a role for regulatory T cells. Since induction of these cells may be dependent on APC, we investigated the effects of M. vaccae treatment on pulmonary CD11c(+) cells. Increased levels of IL-10, TGF-beta and IFN-alpha mRNA were detected in CD11 c(+) cells from M. vaccae-treated allergic mice. We propose that M. vaccae-induced CD11c(+) cells have a potential regulatory role at the site of inflammation through their secretion of immunomodulatory cytokines.
引用
收藏
页码:631 / 638
页数:8
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