Excellent long-term cancer control with elective nephron-sparing surgery for selected renal cell carcinomas measuring more than 4 cm

被引:153
作者
Becker, F [1 ]
Siemer, S
Hack, M
Humke, U
Ziegler, M
Stöckle, M
机构
[1] Univ Saarland, Dept Urol & Paediat Urol, D-6650 Homburg, Germany
[2] Katharinen Hosp, Dept Urol, Stuttgart, Germany
关键词
elective indication; follow-up; larger than 4 cm; nephron-sparing surgery; partial nephrectomy; renal cell carcinoma; survival;
D O I
10.1016/j.eururo.2006.03.003
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Elective nephron-sparing surgery (NSS) for renal cell carcinoma (RCC) < 4 cm has been accepted as alternative to radical nephrectomy (RN). However, NSS for tumours > 4 cm is controversial. We present our experiences and long-term oncologic outcome of RCC > 4 cm treated with NSS in a retrospective single-institutional analysis of 69 patients. Methods: Between 1975 and 2004, elective NSS was performed in 368 patients at our institution, including 69 patients with sporadic, nonmetastatic RCC > 4 cm. Overall and cancer-specific survivals were estimated using the Kaplan-Meier method. Results: Complications were seen in nine patients (13.0%). After a mean follow-up of 6.2 yr (median, 5.8 yr) seven patients (10.1%) had died, none of them of tumour-related causes. Tumour recurrence was detected in four patients (5.8%). The 5-yr overall survival probability was 94.9%. The 10-yr and 15-yr overall survival rates were both 86.7%. Cancer-specific survival was 100% after 5, 10, and 15 yr. Conclusions: Selected patients with localized RCC even > 4 cm can be treated with elective NSS providing optimal long-term outcome. The surgeon's decision for organ-preserving surgery should depend on tumour localisation and technical feasibility rather than on tumour size. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:1058 / 1064
页数:7
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