CD45: all is not yet crystal clear

被引：86

作者：

Holmes, N ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England

来源：

IMMUNOLOGY | 2006年 / 117卷 / 02期

关键词：

CD45; isoforms; phosphatase; polymorphism; protein structure;

D O I：

10.1111/j.1365-2567.2005.02265.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the biology of the first recognized receptor tyrosine phosphatase, CD45, is reviewed.

引用

页码：145 / 155

页数：11

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