A nosocomial outbreak of Pseudomonas aeruginosa isolates expressing the extended-spectrum β-lactamase GES-2 in South Africa

被引：80

作者：

Poirel, L

Weldhagen, GF

De Champs, C

Nordmann, P ^{[1
]}

机构：

[1] Assistance Publ Hop Paris, Hop Bicetre, Fac Med Paris Sud, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Univ Auvergne, Fac Med, Bacteriol Lab, F-63001 Clermont Ferrand, France

[3] Univ Pretoria, Fac Med, Dept Med Microbiol, ZA-0001 Pretoria, South Africa

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 49卷 / 03期

关键词：

D O I：

10.1093/jac/49.3.561

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Eight Pseudomonas aeruginosa clinical strains that produce the clavulanic-acid-inhibited beta-lactamase GES-2 were isolated from patients of a South African hospital from March to July 2000. They were clonally related and each harboured a 150 kb conjugative plasmid carrying a class 1 integron containing a gene cassette encoding GES-2, followed by those for beta-lactamase OXA-5 and an aminoglycoside modifying AAC(3)l-like enzyme. Hence, incidences of infection, several fatal, due to bacteria displaying clavulanate-inhibited resistance to extended-spectrum cephalosporins and reduced susceptibility to imipenem in Pretoria Academic Hospital, South Africa, can be explained, at least in part, by the spread of P. aeruginosa expressing the GES-2 beta-lactamase.

引用

页码：561 / 565

页数：5

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