Synthesis of new derivatives of natural guaianolides

New derivatives with hydroxyl, amino, and keto groups; halides; and N atoms were synthesized based on available guaiane-type sesquiterpene lactones arglabin, artefin, ludartin, and estafiatin isolated from yarrow and wormwood. The structures of the molecules were established using IR, UV, PMR, and C-13 NMR spectral data. The molecular structures of 2, 6, 12, and 14 were proved by x-ray crystal structure analyses.