Genetic mapping of Y-chromosomal DNA markers in Pacific salmon

被引:94
作者
Devlin, RH [1 ]
Biagi, CA [1 ]
Smailus, DE [1 ]
机构
[1] Fisheries & Oceans Canada, W Vancouver, BC V7V 1N6, Canada
关键词
growth hormone; pseudogene; salmon; sex chromosomes; sex determination; Y chromosome;
D O I
10.1023/A:1013759802604
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Sex chromosomes in fish provide an intriguing view of how sex-determination mechanisms evolve in vertebrates. Many fish species with single-factor sex-determination systems do not have cytogenetically-distinguishable sex chromosomes, suggesting that few sex-specific sequences or chromosomal rearrangements are present and that sex-chromosome evolution is thus at an early stage. We describe experiments examining the linkage arrangement of a Y-chromosomal GH pseudogene (GH-Y) sequence in four species of salmon (chum, Oncorhynchus keta; pink, O. gorbuscha; coho, O. kisutch; chinook, O. tshawytscha). Phylogenetic analysis indicates that GH-Y arose early in Oncorhynchus evolution, after this genus had diverged from Salmo and Salvelinus. However, GH-Y has not been detected in some Oncorhynchus species (O. nerka, O. mykiss and O. clarki), consistent with this locus being deleted in some lineages. GH-Y is tightly linked genetically to the sex-determination locus on the Y chromosome and, in chinook salmon, to another Y-linked DNA marker OtY1. GH-Y is derived from an ancestral GH2 gene, but this latter functional GH locus is autosomal or pseudoautosomal. YY chinook salmon are viable and fertile, indicating the Y chromosome is not deficient of vital genetic functions present on the X chromosome, consistent with sex chromosomes that are in an early stage of divergence.
引用
收藏
页码:43 / 58
页数:16
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