The roles of herpes simplex virus in neuroscience

被引:15
作者
Turner, SL
Jenkins, FJ
机构
[1] UNIV PITTSBURGH, SCH MED,PITTSBURGH CANC INST,DEPT PATHOL, DIV BEHAV MED & ONCOL, PITTSBURGH, PA 15261 USA
[2] UNIV PITTSBURGH, SCH PUBL HLTH, PITTSBURGH CANC INST, DEPT MICROBIOL & INFECT DIS, PITTSBURGH, PA 15260 USA
[3] UNIV PITTSBURGH, CTR NEUROSCI, PITTSBURGH, PA 15213 USA
关键词
herpes simplex virus; neuroscience; viral vectors; latency; demyelination; neuro-immune interactions;
D O I
10.3109/13550289709015801
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Herpes simplex virus (HSV) has been a focus of research in many laboratories during the last 30-35 years, with the majority centered on the virus' replication, molecular biology and pathogenesis. Recently, HSV has begun to receive considerable attention in the field of neuroscience, where scientists have begun to use the virus as a tool or model for several areas of investigation. These areas include the construction and development of HSV-based vectors for gene therapy and the use of HSV as a neuronal tracer, as a model for demyelinating disease and to study interactions between the nervous, immune and endocrine systems. The goal of this paper is to review these different roles for HSV in the broad field of neuroscience.
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页码:110 / 125
页数:16
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