Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1
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作者:
Bae, Moon-Kyoung
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Bae, Moon-Kyoung
Kim, Se-Hee
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Kim, Se-Hee
Jeong, Joo-Won
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Jeong, Joo-Won
Lee, You Mie
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Lee, You Mie
Kim, Hae-Sun
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Kim, Hae-Sun
Kim, Su-Ryun
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Kim, Su-Ryun
Yun, Il
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Yun, Il
Bae, Soo-Kyung
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机构:Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Bae, Soo-Kyung
Kim, Kyu-Won
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Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South KoreaSeoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
Kim, Kyu-Won
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机构:
[1] Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
[2] Pusan Natl Univ, Coll Dent, Pusan 602739, South Korea
[3] Pusan Natl Univ, Coll Med, Pusan 602739, South Korea
[4] Kyungpook Natl Univ, Taegu 702701, South Korea
Hypoxia-inducible factor-1 (HIF-1) has a central role in cellular responses to hypoxia, including the transcriptional activation of a number of genes involved in angiogenesis in tumors. We found that curcumin, a natural, biologically active compound isolated from the commonly used spice turmeric, significantly decreases hypoxia-induced HIF-1 alpha protein levels in HepG2 hepatocellular carcinoma cells. Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor. Curcumin also blocked hypoxia-stimulated angiogenesis in vitro and down-regulated HIF-1 alpha and VEGF expression in vascular endothelial cells. These findings suggest that curcumin may play pivotal roles in tumor suppression via the inhibition of HIF-1 alpha-mediated angiogenesis.