A screen of candidates from peaks of linkage: evidence for the involvement of myeloperoxidase in multiple sclerosis

被引：35

作者：

Chataway, J

Sawcer, S

Feakes, R

Coraddu, F

Broadley, S

Jones, HB

Clayton, D

Gray, J

Goodfellow, PN

Compston, A

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[2] Univ Forvie Site, Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB2 2SR, England

[3] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 98卷 / 02期

基金：

英国惠康基金;

关键词：

multiple sclerosis; myeloperoxidase gene; genome screen;

D O I：

10.1016/S0165-5728(99)00089-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We tested 11 microsatellite markers for evidence of transmission distortion in 744 trio families with multiple sclerosis. Ten of the markers lie within or near to candidate genes selected on the basis that they map within the regions of potential linkage identified in our previously reported linkage genome screen, while the eleventh is an anonymous marker which had previously shown modest evidence for transmission distortion in our sibling pair families. Only the marker related to the myeloperoxidase (MPO) gene revealed tentative evidence for linkage disequilibrium and further work on this gene is clearly needed in order to resolve the status of this region in conferring susceptibility to multiple sclerosis. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：208 / 213

页数：6

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