Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study

被引:339
作者
Geleijnse, JM
Launer, LJ
van der Kuip, DAM
Hofman, A
Witteman, JCM
机构
[1] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands
[2] Wageningen Univ, Div Human Nutr & Epidemiol, Wageningen, Netherlands
[3] Natl Inst Aging, Bethesda, MD USA
关键词
tea; flavonoids; myocardial infarction; ischemic heart disease; population-based study; the Rotterdam Study; Netherlands;
D O I
10.1093/ajcn/75.5.880
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Dietary flavonoids may protect against cardiovascular disease, but evidence is still conflicting. Tea is the major source of flavonoids in Western populations. Objective: The association of tea and flavonoid intake with incident myocardial infarction was examined in the general Dutch population. Design: A longitudinal analysis was performed with the use of data from the Rotterdam Study-a population-based study of men and women aged greater than or equal to55 y. Diet was assessed at baseline (1990-1993) with a validated semiquantitative food-frequency questionnaire. The analysis included 4807 subjects with no history of myocardial infarction, who were followed until 31 December 1997. Data were analyzed in a Cox regression model, with adjustment for age, sex, body mass index, smoking status, pack-years of cigarette smoking, education level, and daily intakes of alcohol, coffee, polyunsaturated fat, saturated fat, fiber, vitamin E, and total energy. Results: During 5.6 y of follow-up, a total of 146 first myocardial infarctions occurred, 30 of which were fatal. The relative risk (RR) of incident myocardial infarction was lower in tea drinkers with a daily intake >375 mL (RR: 0.57; 95% CI: 0.33, 0.98) than in nontea drinkers. The inverse association with tea drinking was stronger for fatal events (0.30; 0.09, 0.94) than for nonfatal events (0.68; 0.37, 1.26). The intake of dietary flavonoids (quercetin + kaempferol + myricetin) was significantly inversely associated only with fatal myocardial infarction (0.35, 0.13, 0.98) in upper compared with lower tertiles of intake. Conclusions: An increased intake of tea and flavonoids may contribute to the primary prevention of ischemic heart disease.
引用
收藏
页码:880 / 886
页数:7
相关论文
共 37 条
  • [1] [Anonymous], INT STAT CLASS DIS R
  • [2] Arts ICW, 2001, AM J CLIN NUTR, V74, P227
  • [3] Diagnostic interpretation of electrocardiograms in population-based research: Computer program research physicians, or cardiologists?
    deBruyne, MC
    Kors, JA
    Hoes, AW
    Kruijssen, DACM
    Deckers, JW
    Grosfeld, M
    vanHerpen, G
    Grobbee, DE
    vanBemmel, JH
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1997, 50 (08) : 947 - 952
  • [4] FLAVONOIDS INHIBIT THE OXIDATIVE MODIFICATION OF LOW-DENSITY LIPOPROTEINS BY MACROPHAGES
    DEWHALLEY, CV
    RANKIN, SM
    HOULT, JRS
    JESSUP, W
    LEAKE, DS
    [J]. BIOCHEMICAL PHARMACOLOGY, 1990, 39 (11) : 1743 - 1750
  • [5] Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease
    Duffy, SJ
    Keaney, JF
    Holbrook, M
    Gokce, N
    Swerdloff, PL
    Frei, B
    Vita, JA
    [J]. CIRCULATION, 2001, 104 (02) : 151 - 156
  • [6] Tea and coronary heart disease: Protection through estrogenlike activity?
    Geleijnse, JM
    Witteman, JCM
    Launer, LJ
    Lamberts, SWJ
    Pols, HAP
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (21) : 3328 - 3329
  • [7] Tea flavonoids may protect against atherosclerosis -: The Rotterdam study
    Geleijnse, JM
    Launer, LJ
    Hofman, A
    Pols, HAP
    Witteman, JCM
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (18) : 2170 - 2174
  • [8] ON THE MECHANISM OF ANTITHROMBOTIC ACTION OF FLAVONOIDS
    GRYGLEWSKI, RJ
    KORBUT, R
    ROBAK, J
    SWIES, J
    [J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (03) : 317 - 322
  • [9] Hegarty VM, 2000, AM J CLIN NUTR, V71, P1003
  • [10] FLAVONOID INTAKE AND LONG-TERM RISK OF CORONARY-HEART-DISEASE AND CANCER IN THE 7 COUNTRIES STUDY
    HERTOG, MGL
    KROMHOUT, D
    ARAVANIS, C
    BLACKBURN, H
    BUZINA, R
    FIDANZA, F
    GIAMPAOLI, S
    JANSEN, A
    MENOTTI, A
    NEDELJKOVIC, S
    PEKKARINEN, M
    SIMIC, BS
    TOSHIMA, H
    FESKENS, EJM
    HOLLMAN, PCH
    KATAN, MB
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (04) : 381 - 386