Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake

被引:134
作者
Matson, CA
Wiater, MF
Kuijper, JL
Weigle, DS
机构
[1] ZYMOGENT CORP,SEATTLE,WA 98102
[2] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195
关键词
leptin; satiety; anorectic agent; appetite; energy balance; obesity;
D O I
10.1016/S0196-9781(97)00138-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Both cholecystokinin (CCK), a short-term meal-related satiety signal, and the ob protein leptin, a postulated long-term adiposity hormone, are thought to be important signals in the multiple interacting systems that control appetite and adiposity. We hypothesized that these hormones may synergistically interact to suppress feeding. Following IP administration of leptin (two doses of 50 mu g each) and CCK (2, 4, 8, or 16 mu g) total daily caloric intake was significantly reduced by leptin and CCK compared to leptin alone. These results support the hypothesis that CCK and leptin may synergistically interact to control long-term feeding. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:1275 / 1278
页数:4
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