Imprint switch mechanism indicated by mutations in Prader-Willi and Angelman syndromes

被引:13
作者
Kelsey, G
Reik, W
机构
[1] Lab. Devmtl. Genet. and Imprinting, Babraham Institute, Cambridge
关键词
D O I
10.1002/bies.950190502
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genomic imprinting is an epigenetic mechanism resulting in the preferential expression of the maternal or paternal alleles of a specific subset of genes in the mammalian genome. A key but relatively unexplored question is how imprints are established in the germline. New observations((1)) on two classical imprinting disorders, the Prader-Willi (PWS) and Angelman (AS) syndromes, offer the first genetic insight into this process. Molecular analysis of imprinting mutations that interfere with the appropriate establishment of the maternal and paternal epigenotypes has led to the identification of imprinted transcripts that could be involved in switching imprints in the germlines.
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页码:361 / 365
页数:5
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