学术探索
学术期刊
新闻热点
数据分析
智能评审

Coexistence of independent myelodysplastic and Philadelphia chromosome positive clones in a patient treated with hydroxyurea

被引：10
作者：
Flamm, MJ
Murty, VVVS
Rao, PH
Nichols, GL
机构：
[1] Columbia Univ Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Med, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Pathol, New York, NY 10032 USA
[3] Baylor Coll Med, Texas Childrens Canc Ctr, Dept Pathol, Houston, TX 77030 USA
来源：
LEUKEMIA RESEARCH | 2002年 / 26卷 / 04期
关键词：
chronic myelogenous leukemia; myelodysplastic syndrome; hydroxyurea; monosomy; 7;
D O I：
10.1016/S0145-2126(01)00140-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a patient with Philadelphia chromosome positive (Ph +ve) chronic myelogenous leukemia (CIVIL), treated with hydroxyurea alone, who upon disease progression developed an additional Ph -ve clone containing chromosomal abnormalities typical of myelodysplastic syndrome (MDS). Retrospective analysis of a cryopreserved stem cell specimen from diagnosis confirmed that this second clone developed during the course of treatment. The development of a clone with additional cytogenetic abnormalities in CIVIL has only been reported after leukemogenic treatment, stem cell transplantation or interferon. We report a case of secondary Ph -ve MDS/AML during blast crisis in a patient treated with hydroxyurea for CIVIL. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：417 / 420
页数：4
相关论文
共 11 条
[1]   CLONAL ORIGIN OF PHILADELPHIA-CHROMOSOME NEGATIVE CELLS WITH TRISOMY-8 APPEARING DURING THE COURSE OF ALPHA-INTERFERON THERAPY FOR PH POSITIVE CHRONIC MYELOCYTIC-LEUKEMIA [J].
ARIYAMA, T ;
INAZAWA, J ;
UEMURA, Y ;
KAKAZU, N ;
MAEKAWA, T ;
URASE, F ;
IRIMAJIRI, K ;
HORIUCHI, A ;
NAKAMURA, Y ;
ABE, T .
CANCER GENETICS AND CYTOGENETICS, 1995, 81 (01) :20-23
[2]   SECONDARY PH-POSITIVE CML WITH A MINORITY MONOSOMY-7 CLONE [J].
AUERBACH, HE ;
STELMACH, T ;
LAGUETTE, JG ;
GLICK, JH ;
KANT, JA ;
NOWELL, PC .
CANCER GENETICS AND CYTOGENETICS, 1987, 28 (01) :173-178
[3]   A 2ND CASE OF TRISOMY-8 IN PHILADELPHIA-CHROMOSOME (PH)-NEGATIVE CELLS DURING THE COURSE OF PH-POSITIVE CHRONIC MYELOCYTIC-LEUKEMIA [J].
BILHOUNABERA, C ;
MARIT, G ;
DEVIANNE, I ;
VIARD, F ;
SALZES, S ;
MONTASTRUC, M ;
RENOUX, M ;
BROUSTET, A ;
REIFFERS, J ;
BERNARD, P .
GENES CHROMOSOMES & CANCER, 1993, 6 (04) :255-256
[4]   Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: Report of three cases [J].
Fayad, L ;
Kantarjian, H ;
OBrien, S ;
Seong, D ;
Albitar, M ;
Keating, M ;
Talpaz, M .
LEUKEMIA, 1997, 11 (05) :767-771
[5]   Clonally unrelated BCR-ABL-negative acute myeloblastic leukemia masquerading as blast crisis after busulphan and interferon therapy for BCR-ABL-positive chronic myeloid leukemia [J].
Manley, R ;
Cochrane, J ;
McDonald, M ;
Rigby, S ;
Moore, A ;
Kirk, A ;
Clarke, S ;
Crossen, PE ;
Morris, CM ;
Patton, WN .
LEUKEMIA, 1999, 13 (01) :126-129
[6]  
MITTELMAN F, 1995, INT SYSTEM HUMAN CYT
[7]  
Mittelman F., 1994, CATALOG CHROMOSOME A
[8]   Leukemia and myelodysplasia effect of multiple cytotoxic therapy in essential thrombocythemia [J].
Randi, ML ;
Fabris, F ;
Girolami, A .
LEUKEMIA & LYMPHOMA, 2000, 37 (3-4) :379-385
[9]   Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated with hydroxyurea:: High proportion of cases with 17p deletion [J].
Sterkers, Y ;
Preudhomme, C ;
Laï, JL ;
Demory, JL ;
Caulier, MT ;
Wattel, E ;
Bordessoule, D ;
Bauters, F ;
Fenaux, P .
BLOOD, 1998, 91 (02) :616-622
[10]   Is hydroxyurea leukemogenic in essential thrombocythemia? [J].
Tefferi, A .
BLOOD, 1998, 92 (04) :1459-1460
12