Bioactive ent-kaurene diterpenoids from Annona senegalensis

被引：51

作者：

Fatope, MO

Audu, OT

Takeda, Y

Zeng, L

Shi, G

Shimada, H

McLaughlin, JL

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] BAYERO UNIV,DEPT CHEM,KANO,NIGERIA

[3] UNIV TOKUSHIMA,FAC ARTS & SCI,TOKUSHIMA 770,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 03期

关键词：

D O I：

10.1021/np9601566

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED(50) 1.0 mu g/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED(50) 17-18 mu g/mL). The structure of the new compound, 3, was deduced from spectral evidence.

引用

页码：301 / 303

页数：3

共 30 条

[1] ANTITUMOUR AND ANTIBIOTIC PRINCIPLES OF ANNONA-SENEGALENSIS [J].