Saying a firm 'no' to DNA re-replication

被引：6

作者：

Blow, JJ ^{[1
]}

Prokhorova, TA ^{[1
]}

机构：

[1] Univ Dundee, CRC Chromosome Replicat Res Grp, Dept Biochem, Dundee DD1 5EH, Scotland

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 07期

关键词：

D O I：

10.1038/15611

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication 'origins' must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.

引用

页码：E175 / E177

页数：3

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