Nickel-catalyzed highly regioselective multicomponent coupling of ynamides, aldehydes, and silane: A new access to functionalized enamides

被引：80

作者：

Saito, Nozomi ^{[1
]}

Katayama, Tomoyuki ^{[1
]}

Sato, Yoshihiro ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 17期

基金：

日本学术振兴会;

关键词：

D O I：

10.1021/ol801534e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for preparation of functionalized enamides by a nickel-catalyzed multicomponent coupling of ynamides, aldehydes, and silane has been developed. The coupling reaction proceeded in the presence of a nickel-IMes catalyst to give the corresponding gamma-silyloxyenamide derivative, which has an allylic alcohol moiety in the molecule, in a highly stereoselective manner.

引用

页码：3829 / 3832

页数：4

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