Total synthesis of mycophenolic acid

被引：15

作者：

delaCruz, RA

Talamas, FX

Vazquez, A

Muchowski, JM

机构：

[1] SYNTEX SA CV,DIV INVEST,JIUTEPEC,MORELOS,MEXICO

[2] SYNTEX INC,INST ORGAN CHEM,RES,PALO ALTO,CA 94304

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1997年 / 75卷 / 06期

关键词：

mycophenolic acid; Diels-Alder reaction; pentasubstituted diene;

D O I：

10.1139/v97-078

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A total synthesis of mycophenolic acid is reported. Diels-Alder reaction of [5-methoxy-3-(1-methoxypropenyl)-4,5-dihydrofuran-2-yloxy]-trimethylsilane with 3-benzenesulfinyl-5H-furan-2-one afforded the hexasubstituted nucleus. The side chain was constructed from the unveiled aldehyde.

引用

页码：641 / 645

页数：5

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