Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age

被引:152
作者
Sorensen, N
Murata, K
Budtz-Jorgensen, E
Weihe, P
Grandjean, P
机构
[1] Faroese Hosp Syst, Dept Occupat & Publ Hlth, Torshavn, Faroe Islands, Denmark
[2] Univ Tokyo, Fac Med, Dept Publ Hlth, Tokyo 113, Japan
[3] Univ Copenhagen, Panum Inst, Dept Biostat, DK-2200 Copenhagen, Denmark
[4] Odense Univ, Inst Community Hlth, Odense, Denmark
[5] Boston Univ, Sch Med, Dept Environm Hlth, Boston, MA 02118 USA
[6] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
[7] Sch Publ Hlth, Boston, MA USA
关键词
birth weight; blood pressure; environmental pollution; prenatal exposure delayed effects; preschool child; methylmercury; biomarkers;
D O I
10.1097/00001648-199907000-00006
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Blood pressure in childhood is an important determinant of hypertension risk later in life, and methylmercury exposure is a potential environmental risk factor. A birth cohort of 1,000 children from the Faroe Islands was examined for prenatal exposure to methylmercury, and at age 1 years, blood pressure, heart rate, and heart rate variability were determined. After adjustment for body weight, diastolic and systolic blood pressure increased by 13.9 mmHg [95% confidence limits (CL) = 7.4, 20.4] and 14.6 mmHg (95% CL = 8.3, 20.8), respectively, when cord blood mercury concentrations increased from 1 to 10 mu g/liter cord blood. Above this level, which corresponds to a current exposure limit, no further increase was seen. Birth weight acted as a modifier, with, the mercury effect bring stronger in children with lower birth weights. In boys, heart rate variability decreased with increasing mercury exposures, particularly from 1 to 10 mu g/liter cord blood, at which the variability was reduced by 47%, (95% CL = 14%, 68%). These findings suggest that prenatal exposure to methylmercury may affect the development of cardiovascular homeostasis.
引用
收藏
页码:370 / 375
页数:6
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