ddC- and 3TC-bis(SATE) monophosphate prodrugs overcome cellular resistance mechanisms to HIV-1 associated with cytidine kinase deficiency

被引：16

作者：

Gröschel, B

Himmel, N

Cinatl, J

Périgaud, C

Gosselin, G

Imbach, JL

Doerr, HW

Cinatl, J

机构：

[1] Univ Frankfurt, Inst Med Virol, D-60528 Frankfurt, Germany

[2] Univ Frankfurt, Dept Hematol & Oncol, Ctr Pediat, D-6000 Frankfurt, Germany

[3] Univ Montpellier 2, Chim Bioorgan Lab, F-34095 Montpellier, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041600

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 2',3'-dideoxycytidine (ddC)-resistant T-lymphoid eel line (MOLT-4/8(r)ddC(250)), in which deoxycytidine kinase (dCK) gene-expression was decreased when compared with parental cells, has been selected. Cytotoxic and antiretroviral activity of ddC and 3TC was significantly lower in MOLT-4/8(r)ddC(250) than in parental MOLT-4/8 cells. ddC- and 3TC-bis(SATE)phosphotriesters completely overcame cellular resistance mechanisms and showed comparable both cytotoxic and antiretroviral activity in parental and ddC-resistant cells.

引用

页码：921 / 926

页数：6

共 14 条

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