Regulation of experimental autoimmune encephalomyelitis by chemokines and chemokine receptors

被引：30

作者：

Elhofy, A ^{[1
]}

Kennedy, KJ ^{[1
]}

Fife, BT ^{[1
]}

Karpus, WJ ^{[1
]}

机构：

[1] Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA

来源：

IMMUNOLOGIC RESEARCH | 2002年 / 25卷 / 02期

关键词：

chemokinds; chemokine receptors; encephalomyelitis; autoimmune;

D O I：

10.1385/IR:25:2:167

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this review we summarize the role of chemokines and chemokine receptors in disease pathogenesis and suggest a pathway of events that leads to demyelination and subsequent clinical disease manifestation.

引用

收藏

页码：167 / 175

页数：9

相关论文

共 47 条

[1] C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system [J].

Asensio, VC ;

Lassmann, S ;

Pagenstecher, A ;

Steffensen, SC ;

Henriksen, SJ ;

Campbell, IL .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (04) :1181-1191

[2] A new class of membrane-bound chemokine with a CX(3)C motif [J].

Bazan, JF ;

Bacon, KB ;

Hardiman, G ;

Wang, W ;

Soo, K ;

Rossi, D ;

Greaves, DR ;

Zlotnik, A ;

Schall, TJ .

NATURE, 1997, 385 (6617) :640-644

[3]

Berman JW, 1996, J IMMUNOL, V156, P3017

[4]

Brocke Stefan, 1994, Trends in Microbiology, V2, P250, DOI 10.1016/0966-842X(94)90630-0

[5] Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1/Th2 bias [J].

Charles, PC ;

Weber, KS ;

Cipriani, B ;

Brosnan, CF .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 100 (1-2) :64-73

[6] CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis [J].

Fife, BT ;

Huffnagle, GB ;

Kuziel, WA ;

Karpus, WJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (06) :899-905

[7] CXCL10 (IFN-γ-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis [J].

Fife, BT ;

Kennedy, KJ ;

Paniagua, MC ;

Lukacs, NW ;

Kunkel, SL ;

Luster, AD ;

Karpus, WJ .

JOURNAL OF IMMUNOLOGY, 2001, 166 (12) :7617-7624

[8] Impaired host defense, hematopoiesis, guanulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1 [J].

Gao, JL ;

Wynn, TA ;

Chang, Y ;

Lee, EJ ;

Broxmeyer, HE ;

Cooper, S ;

Tiffany, HL ;

Westphal, H ;

KwonChung, J ;

Murphy, PM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (11) :1959-1968

[9] Expression of chemokines RANTES, MIP-1α and GRO-α correlates with inflammation in acute experimental autoimmune encephalomyelitis [J].

Glabinski, AR ;

Tuohy, VK ;

Ransohoff, RM .

NEUROIMMUNOMODULATION, 1998, 5 (3-4) :166-171

[10] Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis [J].

Glabinski, AR ;

Krakowski, M ;

Han, YL ;

Owens, T ;

Ransohoff, RM .

JOURNAL OF NEUROVIROLOGY, 1999, 5 (01) :95-101

← 1 2 3 4 5 →