NMDA channel regulation by channel-associated protein tyrosine kinase Src

被引：537

作者：

Yu, XM ^{[1
]}

Askalan, R ^{[1
]}

Keil, GJ ^{[1
]}

Salter, MW ^{[1
]}

机构：

[1] UNIV TORONTO,HOSP SICK CHILDREN,DEPT PHYSIOL,TORONTO,ON M5G 1X8,CANADA

来源：

SCIENCE | 1997年 / 275卷 / 5300期

关键词：

D O I：

10.1126/science.275.5300.674

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The N-methyl-D-aspartate (NMDA) receptor mediates synaptic transmission and plasticity in the central nervous system (CNS) and is regulated by tyrosine phosphorylation. In membrane patches excised from mammalian central neurons, the endogenous tyrosine kinase Src was shown to regulate the activity of NMDA channels. The action of Src required a sequence [Src(40-58)] within the noncatalytic, unique domain of Src. In addition, Src coprecipitated with NMDA receptor proteins. Finally, endogenous Src regulated the function of NMDA receptors at synapses. Thus, NMDA receptor regulation by Src may be important in development, plasticity, and pathology in the CNS.

引用

页码：674 / 678

页数：5

共 35 条

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