Shared resources between the neural and immune systems: semaphorins join the ranks

被引：41

作者：

Spriggs, MK ^{[1
]}

机构：

[1] Immunex Corp, Dept Mol Biol, Seattle, WA 98101 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(99)80065-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The semaphorin family of molecules contains members known to deliver guidance cues to migrating axons during development. Semaphorins also have been identified on the surface of hematopoietic cells and, interestingly, in the genomes of certain lytic viruses. Recent studies indicate that semaphorins bind with high affinity to at least two different receptor families and are biologically active on immune cells as well as neuronal cells.

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页码：387 / 391

页数：5

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