Bacterial mechanosensitive channels: integrating physiology, structure and function

被引：98

作者：

Blount, P ^{[1
]}

Moe, PC ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Physiol, Dallas, TX 75235 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0966-842X(99)01594-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When confronted with hypo-osmotic stress, many bacterial species are able rapidly to adapt to the increase in cell turgor pressure by jettisoning cytoplasmic solutes into the medium through membrane-tension-gated channels. Physiological studies have confirmed the importance of these channels in osmoregulation. Mutagenesis of one of these channels, combined with structural information derived from X-ray crystallography, has given the first clues of how a mechanosensitive channel senses and responds to membrane tension.

引用

页码：420 / 424

页数：7

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