Comparison of ondansetron and cyclizine for prevention of nausea and vomiting after day-case gynaecological laparoscopy

被引:32
作者
Cholwill, JM
Wright, W
Hobbs, GJ
Curran, J
机构
[1] City Hosp Nottingham, Dept Anaesthesia, Nottingham NG5 1PB, England
[2] Univ Nottingham, Queens Med Ctr, Dept Anaesthesia, Nottingham NG7 2UH, England
关键词
vomiting; nausea; antiemetics; surgical factors; pharmacology; ondansetron; cyclizine; surgery; day-case; laparoscopy;
D O I
10.1093/bja/83.4.611
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We have compared ondansetron 4 mg i.v. and cyclizine 50 mg i.v., in a double-blind, randomized, placebo-controlled study for the prevention of postoperative nausea and vomiting (PONV) for 24 h after day-case gynaecological laparoscopy. Compared with placebo (n = 58), ondansetron (n = 60) and cyclizine (n = 57) reduced significantly the incidence of moderate or severe nausea (30% and 23% vs 52%; P = 0.02 and P = 0.001, respectively) and requirement for escape antiemetic (28% and 16% vs 47%; P = 0.04 and P < 0.001, respectively) before discharge from hospital. There were no significant differences in PONV after discharge. Significantly more patients suffered no PONV before and after discharge after ondansetron and cyclizine compared with placebo (31% and 33% vs 12%; P = 0.02 and P < 0.01, respectively). For diagnostic laparoscopy (n = 74), fewer patients received escape antiemetic after cyclizine than after ondansetron (4% vs 37%; P < 0.01); for laparoscopic sterilization (n = 101), both antiemetics were equally effective. Ondansetron and cyclizine both reduced severe and moderate nausea and the need for antiemetic therapy after day-case gynaecological laparoscopy.
引用
收藏
页码:611 / 614
页数:4
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