Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2

被引:56
作者
Wilson, MP [1 ]
Sun, Y [1 ]
Cao, L [1 ]
Majerus, PW [1 ]
机构
[1] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
关键词
D O I
10.1074/jbc.M106605200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phosphorylation of inositol 1,3,4-trisphosphate by inositol 1,3,4-trisphosphate 5/6-kinase is the first committed step in the formation of higher phosphorylated forms of inositol. We have shown that the eight proteins called the COP9 signalosome complex copurify with calf brain 5/6-kinase. Because the complex has been shown to phosphorylate c-Jun an vitro, we tested both the complex and 5/6-kinase and found that both are able to phosphorylate c-Jun and ATF-2 on serine/threonine residues. These findings establish a link between two major signal transduction systems: the inositol phosphates and the stress response system.
引用
收藏
页码:40998 / 41004
页数:7
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