Nesfatin-1 increases anxiety- and fear-related behaviors in the rat

被引:197
作者
Merali, Z. [1 ,2 ,3 ,4 ]
Cayer, C. [1 ,2 ]
Kent, P. [1 ,2 ]
Anisman, H. [1 ,5 ]
机构
[1] Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada
[2] Univ Ottawa, Dept Psychol, Ottawa, ON K1N 6N5, Canada
[3] Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada
[4] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1N 6N5, Canada
[5] Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada
基金
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词
Nesfatin-1; Anxiety; Fear; Elevated plus maze; Novelty; Fear-potentiated startle; Conditioned emotional response;
D O I
10.1007/s00213-008-1252-2
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Rationale Nesfatin-1, derived from the protein NEFA/nucleobindin2 (NUCB2), is a newly identified peptide that acts as a potent satiety agent. It has been reported that peptides involved in the regulation of ingestive behavior are also involved in the regulation of the stress response. However, the relation between nesfatin-1 and stressor-related behaviors like anxiety and/or fear has not yet been investigated. Objective The effects of intracerebroventricular (ICV) injection of nesfatin-1 (0, 5, and 25 pmol/3 mu l) were assessed in several paradigms that are thought to reflect anxiety and/or fear in rats. Results Consistent with an anxiogenic effect, nesfatin-1 dose-dependently decreased the percentage of time spent on the open arms of the elevated plus maze, increased latency to approach, and decreased consumption of a palatable snack in an anxiogenic (unfamiliar) environment. Moreover, ICV nesfatin-1 increased the fear-potentiated startle response and the time spent freezing to both context and conditioned cues in a conditioned emotional response test. Conclusions These findings suggest that in addition to its role as a satiety peptide, nesfatin-1 may also be involved in the mediation of anxiety- and/or fear-related responses.
引用
收藏
页码:115 / 123
页数:9
相关论文
共 59 条
[1]
Leptin [J].
Ahima, RS ;
Flier, JS .
ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437
[2]
REGULATION OF ACTIVITY IN THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS IS INTEGRAL TO A LARGER HYPOTHALAMIC SYSTEM THAT DETERMINES CALORIC FLOW [J].
AKANA, SF ;
STRACK, AM ;
HANSON, ES ;
DALLMAN, MF .
ENDOCRINOLOGY, 1994, 135 (03) :1125-1134
[3]
FOOD-INDUCED CORTISOL SECRETION IS MEDIATED BY CENTRAL ALPHA-1 ADRENOCEPTOR MODULATION OF PITUITARY ACTH-SECRETION [J].
ALDAMLUJI, S ;
IVESON, T ;
THOMAS, JM ;
PENDLEBURY, DJ ;
REES, LH ;
BESSER, GM .
CLINICAL ENDOCRINOLOGY, 1987, 26 (05) :629-636
[4]
Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders [J].
Anisman, Hymie ;
Merali, Zul ;
Hayley, Shawn .
PROGRESS IN NEUROBIOLOGY, 2008, 85 (01) :1-74
[5]
CROUCHING AS AN INDEX OF FEAR [J].
BLANCHARD, RJ ;
BLANCHARD, DC .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1969, 67 (03) :370-+
[6]
Nesfatin-1: Distribution and interaction with a g protein-coupled receptor in the rat brain [J].
Brailoiu, G. Cristina ;
Dun, Siok L. ;
Brailoiu, Eugen ;
Inan, Saadet ;
Yang, Jun ;
Chang, Jaw Kang ;
Dun, Nae J. .
ENDOCRINOLOGY, 2007, 148 (10) :5088-5094
[7]
Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on [J].
Carobrez, AP ;
Bertoglio, LJ .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (08) :1193-1205
[8]
Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents [J].
Chaki, S ;
Ogawa, S ;
Toda, Y ;
Funakoshi, T ;
Okuyama, S .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 474 (01) :95-101
[9]
BIOLOGICAL ACTIONS OF CHOLECYSTOKININ [J].
CRAWLEY, JN ;
CORWIN, RL .
PEPTIDES, 1994, 15 (04) :731-755
[10]
ETHOPHARMACOLOGICAL ANALYSIS OF RAT BEHAVIOR ON THE ELEVATED PLUS-MAZE [J].
CRUZ, APM ;
FREI, F ;
GRAEFF, FG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1994, 49 (01) :171-176