Adrenomedullin and related peptides: receptors and accessory proteins

被引：29

作者：

Muff, R

Born, W

Fischer, JA

机构：

[1] Univ Zurich, Res Lab Calcium Metab, Dept Orthoped Surg, Klin Balgrist, CH-8008 Zurich, Switzerland

[2] Univ Zurich, Res Lab Calcium Metab, Dept Med, Klin Balgrist, CH-8008 Zurich, Switzerland

来源：

PEPTIDES | 2001年 / 22卷 / 11期

关键词：

adrenomedullin; amylin; calcitonin gene related peptide; complex; heterodimer; receptor activity modifying protein;

D O I：

10.1016/S0196-9781(01)00515-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adrenomedullin (AM), alpha- and beta -calcitonin gene-related peptide (CGRP), amylin and calcitonin (CT) are structurally and functionally related peptides. The structure of a receptor for CT (CTR) was elucidated in 1991 through molecular cloning, but the structures of the receptors for the other three peptides had yet to be elucidated. The discovery of receptor-activity-modifying proteins (RAMP) 1 and -2 and their co-expression with an orphan receptor, calcitonin receptor-like receptor (CRLR) has led to the elucidation of functional CGRP and AM receptors, respectively. RAMP1 and -3 which are co-expressed with CTR revealed two amylin receptor isotypes. Molecular interactions between CRLR and RAMPS are involved in their transport to the cell surface. Heterodimeric complexes between CRLR or CTR and RAMPs are required for ligand recognition. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

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页码：1765 / 1772

页数：8

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