Visfatin, Leptin, and TNF-α: Interrelated Adipokines in Insulin-Resistant Clinical and Subclinical Hypothyroidism

被引:30
作者
Guzel, Savas [1 ]
Seven, Arzu [2 ]
Guzel, Eda Celik [3 ]
Buyuk, Banu [4 ]
Celebi, Aslan [4 ]
Aydemir, Birsen [5 ]
机构
[1] Namik Kemal Univ, Fac Med, Dept Biochem, Tekirdag, Turkey
[2] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey
[3] Namik Kemal Univ, Fac Med, Dept Family Phys, Tekirdag, Turkey
[4] Taksim Training & Res Hosp, Dept Internal Med, Istanbul, Turkey
[5] Sakarya Univ, Fac Med, Dept Biophys, Sakarya, Turkey
关键词
Visfatin; Leptin; Adipokines; Insulin resistant; Hypothyroidism; TYPE-2; DIABETES-MELLITUS; COLONY-ENHANCING FACTOR; ADIPONECTIN LEVELS; IMMUNE-RESPONSE; REFERENCE RANGE; ADIPOSE-TISSUE; VISCERAL FAT; GLUCOSE; ASSOCIATION; SENSITIVITY;
D O I
10.3109/07435800.2012.760588
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Purpose. This study is designed to evaluate the interrelationships among adipokines-visfatin, leptin, and tumor necrosis factor-alpha (TNF-alpha)- and insulin resistance (IR) in overt (n = 40) and subclinic hypothyroid (n = 25) patients and compare our findings with sex and body mass index-matched healthy controls (n = 25). Methods. Serum visfatin, leptin, and TNF-alpha levels were measured by enzyme-linked immunosorbent assay and C-reactive protein by immunoturbidimetry. Thyroid status (TSH, FT3, FT4) and lipid status (triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, total cholesterol) parameters were measured. IR was determined by homeostatic model assessment (HOMA-IR) and McAuley (McA) indices. Results. HOMA-IR (p < 0.05) and McA indices (p < 0.01) revealed the presence of IR in overt hypothyroid patients. C-reactive protein, TNF-alpha, leptin, and visfatin levels were significantly higher (p < 0.01, p < 0.01, p < 0.001, and p < 0.001) in overt hypothyroid patients than euthyroid control group. Subclinic hypothyroid patients were observed to have significantly higher leptin and visfatin levels (p < 0.05) than euthyroid control group. In overt hypothyroid patients, we found plasma visfatin to be significantly positively correlated with HOMA-IR index (r = 0.336, p < 0.05) and body mass index (r = 0.445, p < 0.01) and negatively correlated with McA index (r = -0.574, p < 0.01). Conclusion. This study demonstrates the presence of IR in overt hypothyroid patients by HOMA and McA indices. Increased levels of visfatin, leptin, and TNF-alpha in overt and subclinic hypothyroid patients and the correlations among these adipokines highlighten their crucial role in the IR-associated disorders.
引用
收藏
页码:184 / 194
页数:11
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