The end of almost 10 years of negative RCTs in advanced hepatocellular carcinoma

被引：36

作者：

Nault, Jean-Charles ^{[1
,2
,3
,4
]}

机构：

[1] INSERM, Genom Fonct Tumeurs Solides, Unite Mixte Rech 1162, Paris, France

[2] Hop Univ Paris Seine St Denis, Hop Jean Verdier, AP HP, Liver Unit, Bondy, France

[3] Univ Paris 13, Unite Format & Rech Sante Med & Biol Humaine, Communaute Univ & Etablissements, Sorbonne Paris Cite, Paris, France

[4] Hop Univ Paris Seine St Denis, AP HP, Pole Act Cancerol Specialisee, Serv Hepatol, Site Jean Verdier, F-93143 Bondy, France

来源：

LANCET | 2017年 / 389卷 / 10064期

关键词：

SORAFENIB;

D O I：

10.1016/S0140-6736(16)32480-1

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页码：4 / 6

页数：3

共 12 条

[1]

[Anonymous], LANCET

[2]

Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma [J].

Bruix, Jordi ;

Reig, Maria ;

Sherman, Morris .

GASTROENTEROLOGY, 2016, 150 (04) :835-853

[3]

Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial [J].

Bruix, Jordi ;

Takayama, Tadatoshi ;

Mazzaferro, Vincenzo ;

Chau, Gar-Yang ;

Yang, Jiamei ;

Kudo, Masatoshi ;

Cai, Jianqiang ;

Poon, Ronnie T. ;

Han, Kwang-Hyub ;

Tak, Won Young ;

Lee, Han Chu ;

Song, Tianqiang ;

Roayaie, Sasan ;

Bolondi, Luigi ;

Lee, Kwan Sik ;

Makuuchi, Masatoshi ;

Souza, Fabricio ;

Le Berre, Marie-Aude ;

Meinhardt, Gerold ;

Llovet, Josep M. .

LANCET ONCOLOGY, 2015, 16 (13) :1344-1354

[4]

Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE-5-a population-based study [J].

De Angelis, Roberta ;

Sant, Milena ;

Coleman, Michel P. ;

Francisci, Silvia ;

Baili, Paolo ;

Pierannunzio, Daniela ;

Trama, Annalisa ;

Visser, Otto ;

Brenner, Hermann ;

Ardanaz, Eva ;

Bielska-Lasota, Magdalena ;

Engholm, Gerda ;

Nennecke, Alice ;

Siesling, Sabine ;

Berrino, Franco ;

Capocaccia, Riccardo .

LANCET ONCOLOGY, 2014, 15 (01) :23-34

[5]

Hepatocellular carcinoma [J].

Forner, Alejandro ;

Llovet, Josep M. ;

Bruix, Jordi .

LANCET, 2012, 379 (9822) :1245-1255

[6]

Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial [J].

Lencioni, Riccardo ;

Llovet, Josep M. ;

Han, Guohong ;

Tak, Won Young ;

Yang, Jiamei ;

Guglielmi, Alfredo ;

Paik, Seung Woon ;

Reig, Maria ;

Kim, Do Young ;

Chau, Gar-Yang ;

Luca, Angelo ;

Ruiz del Arbol, Luis ;

Leberre, Marie-Aude ;

Niu, Woody ;

Nicholson, Kate ;

Meinhardt, Gerold ;

Bruix, Jordi .

JOURNAL OF HEPATOLOGY, 2016, 64 (05) :1090-1098

[7]

Sorafenib in advanced hepatocellular carcinoma [J].

Llovet, Josep M. ;

Ricci, Sergio ;

Mazzaferro, Vincenzo ;

Hilgard, Philip ;

Gane, Edward ;

Blanc, Jean-Frederic ;

Cosme de Oliveira, Andre ;

Santoro, Armando ;

Raoul, Jean-Luc ;

Forner, Alejandro ;

Schwartz, Myron ;

Porta, Camillo ;

Zeuzem, Stefan ;

Bolondi, Luigi ;

Greten, Tim F. ;

Galle, Peter R. ;

Seitz, Jean-Francois ;

Borbath, Ivan ;

Haussinger, Dieter ;

Giannaris, Tom ;

Shan, Minghua ;

Moscovici, Marius ;

Voliotis, Dimitris ;

Bruix, Jordi .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) :378-390

[8]

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions [J].

Nault, Jean Charles ;

Mallet, Maxime ;

Pilati, Camilla ;

Calderaro, Julien ;

Bioulac-Sage, Paulette ;

Laurent, Christophe ;

Laurent, Alexis ;

Cherqui, Daniel ;

Balabaud, Charles ;

Zucman Rossi, Jessica .

NATURE COMMUNICATIONS, 2013, 4

[9]

Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib [J].

Reig, Maria ;

Torres, Ferran ;

Rodriguez-Lope, Carlos ;

Forner, Alejandro ;

LLarch, Neus ;

Rimola, Jordi ;

Darnell, Anna ;

Rios, Jose ;

Ayuso, Carmen ;

Bruix, Jordi .

JOURNAL OF HEPATOLOGY, 2014, 61 (02) :318-324

[10]

Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study [J].

Santoro, Armando ;

Rimassa, Lorenza ;

Borbath, Ivan ;

Daniele, Bruno ;

Salvagni, Stefania ;

Van Laethem, Jean Luc ;

Van Vlierberghe, Hans ;

Trojan, Joerg ;

Kolligs, Frank T. ;

Weiss, Alan ;

Miles, Steven ;

Gasbarrini, Antonio ;

Lencioni, Monica ;

Cicalese, Luca ;

Sherman, Morris ;

Gridelli, Cesare ;

Buggisch, Peter ;

Gerken, Guido ;

Schmid, Roland M. ;

Boni, Corrado ;

Personeni, Nicola ;

Hassoun, Ziad ;

Abbadessa, Giovanni ;

Schwartz, Brian ;

Von Roemeling, Reinhard ;

Lamar, Maria E. ;

Chen, Yinpu ;

Porta, Camillo .

LANCET ONCOLOGY, 2013, 14 (01) :55-63

← 1 2 →