Apoptosis and cancer: When BAX is TRAILing away

被引：57

作者：

Roth, W ^{[1
]}

Reed, JC ^{[1
]}

机构：

[1] Burnham Inst, San Diego, CA USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 03期

关键词：

D O I：

10.1038/nm0302-216

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of anticancer therapies that target apoptosis pathways may be hampered by resistance of certain tumor cells to death signals. New findings show that tumor cells lacking the pro-apoptotic protein Bax are resistant to apoptosis induced by the death ligand TRAIL, but that chemotherapeutic drugs can restore their sensitivity to TRAIL. (pages 274–281)

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页码：216 / 218

页数：3

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