Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site

被引：197

作者：

Platz, Anton ^{[1
]}

Egyhazi, Suzanne ^{[1
]}

Ringborg, Wrik ^{[1
]}

Hansson, Johan ^{[1
]}

机构：

[1] Karolinska Univ Hosp Solna, Canc Ctr Karolinska, Karolinska Inst, Dept Oncol Pathol, S-17176 Stockholm, Sweden

来源：

MOLECULAR ONCOLOGY | 2008年 / 1卷 / 04期

关键词：

Malignant melanoma; NRAS; BRAF; Mutation; Classification; Sunlight; UV-radiation;

D O I：

10.1016/j.molonc.2007.12.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A majority of cutaneous melanomas show activating mutations in the NRAS or BRAF proto-oncogenes, components of the Ras-Raf-Mek-Erk signal transduction pathway. Consistent data demonstrate the early appearance, in a mutually exclusive manner, of these mutations. The purpose of this paper is to summarize the literature on NRAS and BRAF activating mutations in melanoma tumors with respect to available data on histogenetic classification as well as body site and presumed UV-exposure. Common alterations of the signal transducing network seem to represent molecular hallmarks of cutaneous melanomas and therefore should continue to strongly stimulate design and testing of targeted molecular interventions. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：395 / 405

页数：11

共 89 条

[1] BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival [J].