Anti-immunoglobulin E for the treatment of allergic disease

被引:7
作者
Busse, William [1 ]
Neaville, William [1 ]
机构
[1] Univ Wisconsin, Dept Med, Allergy & Clin Immunol Sect, Madison, WI 53792 USA
关键词
D O I
10.1097/00130832-200102000-00017
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
IgE plays a central role in allergic disease and participates in the associated inflammatory process. A mainstay of treatment of allergic disease, including asthma, is allergen avoidance and treatment of symptoms. Presently, the most effective treatments for allergic diseases are directed towards a regulation of the inflammatory process with corticosteroids. An exciting new approach is anti-IgE (rhuMAb-E25), which would regulate the allergic process at the level of IgE. The following information will review recent experiences with anti-IgE and discuss the conditions in which this approach may be effective. (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:105 / 108
页数:4
相关论文
共 8 条
[1]   Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis [J].
Ädelroth, E ;
Rak, S ;
Haahtela, T ;
Aasand, G ;
Rosenhall, L ;
Zetterstrom, O ;
Byrne, A ;
Champain, K ;
Thirlwell, J ;
Della Cioppa, G ;
Sandström, T .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (02) :253-259
[2]   Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response [J].
Boulet, LP ;
Chapman, KR ;
Cote, J ;
Kalra, S ;
Bhagat, R ;
Swystun, VA ;
Laviolette, M ;
Cleland, LD ;
Deschesnes, F ;
Su, JQ ;
DeVault, A ;
Fick, RB ;
Cockcroft, DW .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (06) :1835-1840
[3]   Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis [J].
Casale, TB ;
Bernstein, IL ;
Busse, WW ;
LaForce, CF ;
Tinkelman, DG ;
Stoltz, RR ;
Dockhorn, RJ ;
Reimann, J ;
Su, JQ ;
Fick, RB ;
Adelman, DC .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 100 (01) :110-121
[4]   The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects [J].
Fahy, JV ;
Fleming, HE ;
Wong, HH ;
Liu, JT ;
Su, JQ ;
Reimann, J ;
Fick, RB ;
Boushey, HA .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (06) :1828-1834
[5]   Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects [J].
Fahy, JV ;
Cockcroft, DW ;
Boulet, LP ;
Wong, HH ;
Deschesnes, F ;
Davis, EE ;
Ruppel, J ;
Su, JQ ;
Adelman, DC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (03) :1023-1027
[6]   Suppression of immediate and late responses to antigen by a non-anaphylactogenic anti-IgE antibody in a murine model of asthma [J].
Haile, S ;
Lefort, J ;
Eum, SY ;
Dumarey, C ;
Huerre, M ;
Heusser, C ;
Vargaftig, BB .
EUROPEAN RESPIRATORY JOURNAL, 1999, 13 (05) :961-969
[7]  
Lötvall J, 1999, CURR PHARM DESIGN, V5, P757
[8]   Treatment of allergic asthma with monoclonal anti-IgE antibody [J].
Milgrom, H ;
Fick, RB ;
Su, JQ ;
Reimann, JD ;
Bush, RK ;
Watrous, ML ;
Metzger, WJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (26) :1966-1973