The first crystal structure of tyrosinase: All questions answered?

被引：273

作者：

Decker, Heinz ^{[1
]}

Schweikardt, Thorsten

Tuczek, Felix

机构：

[1] Univ Mainz, Inst Mol Biophys, D-55099 Mainz, Germany

[2] Univ Kiel, Inst Anorgan Chem, D-24098 Kiel, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 28期

关键词：

bioinorganic chemistry; copper; metalloenzymes; protein structures; tyrosinase;

D O I：

10.1002/anie.200601255

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Tyrosinases are essential enzymes that occur in all organisms and belong to the class of type3 copper proteins. The first crystal structure of a tyrosinase (from Streptomyces castaneoglobisporus) has been achieved and offers important insights into the mechanism of phenol hydroxylation (see scheme; Cu blue, O red, substrate orange; trans-axial position on CuA: gray dot), the process of activation, and the incorporation of copper. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4546 / 4550

页数：5

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