Melatonin improves metabolic syndrome induced by high fructose intake in rats

被引:94
作者
Kitagawa, Akira [2 ]
Ohta, Yoshiji [1 ]
Ohashi, Koji [3 ]
机构
[1] Fujita Hlth Univ, Sch Med, Dept Chem, Toyoake, Aichi 4701192, Japan
[2] Shigakkan Univ, Fac Wellness, Dept Nutr, Obu, Japan
[3] Fujita Hlth Univ, Sch Hlth Sci, Fac Med Technol, Dept Clin Biochem, Toyoake, Aichi 4701192, Japan
关键词
dyslipidemia; High fructose feeding (rat); hyperuricemia; insulin resistance; melatonin; metabolic syndrome; oxidative stress; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; SWEETENED BEVERAGES; WEIGHT-GAIN; URIC-ACID; SENSITIVITY; ADIPONECTIN; CONSUMPTION; GLUCOSE;
D O I
10.1111/j.1600-079X.2011.00955.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats. Feeding of a diet containing 60% fructose (HFD) for 4 or 6 wk caused increased serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, leptin, and lipid peroxide concentrations as well as hepatic triglyceride and cholesterol concentrations, and relative intra-abdominal fat and liver weights. The 4- or 6-wk HFD feeding reduced serum high-density lipoprotein cholesterol and adiponectin concentrations. The 6-wk HFD feeding increased serum tumor necrosis factor-a concentration and hepatic lipid peroxide concentration and lowered hepatic reduced glutathione concentration. Daily intraperitoneal administration of melatonin (1 or 10 mg/kg body weight), starting at 4-wk HFD feeding, attenuated these changes at 6-wk HFD feeding more effectively at its higher dose than at its lower dose. In an oral glucose tolerance test, rats with 4- or 6-wk HFD feeding showed higher serum insulin response curve and normal serum glucose response curve when compared with the corresponding animals that received the control diet. The 4- or 6-wk HFD feeding caused insulin resistance, judging from the scores of HOMR-IR and QUICKI, which are indices of insulin resistance. The daily administered melatonin (1 or 10 mg/kg body weight) ameliorated the higher serum insulin response curve in the oral glucose tolerance test and insulin resistance at 6-wk HFD feeding more effectively at its higher dose than at its lower dose. These results indicate that melatonin improves metabolic syndrome induced by high fructose intake in rats.
引用
收藏
页码:403 / 413
页数:11
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