Tissue-specificity in cancer: The rule, not the exception

被引：124

作者：

Haigis, Kevin M. ^{[1
,2
,3
]}

Cichowski, Karen ^{[3
,4
,5
]}

Elledge, Stephen J. ^{[3
,4
,5
,6
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Canc Res Inst, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Div Genet, 75 Francis St, Boston, MA 02115 USA

[5] Harvard Med Sch, Ludwig Ctr Harvard, Boston, MA 02215 USA

[6] Harvard Med Sch, Howard Hughes Med Inst, Dept Genet, Program Virol, Boston, MA 02115 USA

来源：

SCIENCE | 2019年 / 363卷 / 6432期

关键词：

INHIBITION;

D O I：

10.1126/science.aaw3472

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

[No abstract available]

引用

页码：1150 / 1151

页数：2

共 12 条

[1]

GATA3 in Development and Cancer Differentiation: Cells GATA Have It! [J].

Chou, Jonathan ;

Provot, Sylvain ;

Werb, Zena .

JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 222 (01) :42-49

[2]

EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF-Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib [J].

Corcoran, Ryan B. ;

Ebi, Hiromichi ;

Turke, Alexa B. ;

Coffee, Erin M. ;

Nishino, Michiya ;

Cogdill, Alexandria P. ;

Brown, Ronald D. ;

Della Pelle, Patricia ;

Dias-Santagata, Dora ;

Hung, Kenneth E. ;

Flaherty, Keith T. ;

Piris, Adriano ;

Wargo, Jennifer A. ;

Settleman, Jeffrey ;

Mino-Kenudson, Mari ;

Engelman, Jeffrey A. .

CANCER DISCOVERY, 2012, 2 (03) :227-235

[3]

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome [J].

Davoli, Teresa ;

Xu, Andrew Wei ;

Mengwasser, Kristen E. ;

Sack, Laura M. ;

Yoon, John C. ;

Park, Peter J. ;

Elledge, Stephen J. .

CELL, 2013, 155 (04) :948-962

[4]

The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients [J].

Elledge, SJ ;

Amon, A .

CANCER CELL, 2002, 1 (02) :129-132

[5]

HER kinase inhibition in patients with HER2-and HER3-mutant cancers [J].

Hyman, David M. ;

Piha-Paul, Sarina A. ;

Won, Helen ;

Rodon, Jordi ;

Saura, Cristina ;

Shapiro, Geoffrey I. ;

Juric, Dejan ;

Quinn, David I. ;

Moreno, Victor ;

Doger, Bernard ;

Mayer, Ingrid A. ;

Boni, Valentina ;

Calvo, Emiliano ;

Loi, Sherene ;

Lockhart, Albert C. ;

Erinjeri, Joseph P. ;

Scaltriti, Maurizio ;

Ulaner, Gary A. ;

Patel, Juber ;

Tang, Jiabin ;

Beer, Hannah ;

Selcuklu, S. Duygu ;

Hanrahan, Aphrothiti J. ;

Bouvier, Nancy ;

Melcer, Myra ;

Murali, Rajmohan ;

Schram, Alison M. ;

Smyth, Lillian M. ;

Jhaveri, Komal ;

Li, Bob T. ;

Drilon, Alexander ;

Harding, James J. ;

Iyer, Gopa ;

Taylor, Barry S. ;

Berger, Michael F. ;

Cutler, Richard E., Jr. ;

Xu, Feng ;

Butturini, Anna ;

Eli, Lisa D. ;

Mann, Grace ;

Farrell, Cynthia ;

Lalani, Alshad S. ;

Bryce, Richard P. ;

Arteaga, Carlos L. ;

Meric-Bernstam, Funda ;

Baselga, Jose ;

Solit, David B. .

NATURE, 2018, 554 (7691) :189-194

[6]

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns [J].

John, Sam ;

Sabo, Peter J. ;

Thurman, Robert E. ;

Sung, Myong-Hee ;

Biddie, Simon C. ;

Johnson, Thomas A. ;

Hager, Gordon L. ;

Stamatoyannopoulos, John A. .

NATURE GENETICS, 2011, 43 (03) :264-U116

[7]

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer [J].

Niederst, Matthew J. ;

Sequist, Lecia V. ;

Poirier, John T. ;

Mermel, Craig H. ;

Lockerman, Elizabeth L. ;

Garcia, Angel R. ;

Katayama, Ryohei ;

Costa, Carlotta ;

Ross, Kenneth N. ;

Moran, Teresa ;

Howe, Emily ;

Fulton, Linnea E. ;

Mulvey, Hillary E. ;

Bernardo, Lindsay A. ;

Mohamoud, Farhiya ;

Miyoshi, Norikatsu ;

VanderLaan, Paul A. ;

Costa, Daniel B. ;

Jaenne, Pasi A. ;

Borger, Darrell R. ;

Ramaswamy, Sridhar ;

Shioda, Toshi ;

Iafrate, Anthony J. ;

Getz, Gad ;

Rudin, Charles M. ;

Mino-Kenudson, Mari ;

Engelman, Jeffrey A. .

NATURE COMMUNICATIONS, 2015, 6

[8]

Toward precision medicine in glioblastoma: the promise and the challenges [J].

Prados, Michael D. ;

Byron, Sara A. ;

Tran, Nhan L. ;

Phillips, Joanna J. ;

Molinaro, Annette M. ;

Ligon, Keith L. ;

Wen, Patrick Y. ;

Kuhn, John G. ;

Mellinghoff, Ingo K. ;

de Groot, John F. ;

Colman, Howard ;

Cloughesy, Timothy F. ;

Chang, Susan M. ;

Ryken, Timothy C. ;

Tembe, Waibhav D. ;

Kiefer, Jeffrey A. ;

Berens, Michael E. ;

Craig, David W. ;

Carpten, John D. ;

Trent, Jeffrey M. .

NEURO-ONCOLOGY, 2015, 17 (08) :1051-1063

[9]

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR [J].

Prahallad, Anirudh ;

Sun, Chong ;

Huang, Sidong ;

Di Nicolantonio, Federica ;

Salazar, Ramon ;

Zecchin, Davide ;

Beijersbergen, Roderick L. ;

Bardelli, Alberto ;

Bernards, Rene .

NATURE, 2012, 483 (7387) :100-U146

[10]

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns [J].

Sack, Laura Magill ;

Davoli, Teresa ;

Li, Mamie Z. ;

Li, Yuyang ;

Xu, Qikai ;

Naxerova, Kamila ;

Wooten, Eric C. ;

Bernardi, Ronald J. ;

Martin, Timothy D. ;

Chen, Ting ;

Leng, Yumei ;

Liang, Anthony C. ;

Scorsone, Kathleen A. ;

Westbrook, Thomas F. ;

Wong, Kwok-Kin ;

Elledge, Stephen J. .

CELL, 2018, 173 (02) :499-+

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