Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation

被引：29

作者：

Chen, Q

Yoshida, H

Schubert, D

Maher, P

Mallory, M

Masliah, E

机构：

[1] Salk Inst Biol Studies, Cellular Neurobiol Lab, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA USA

[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2001年 / 159卷 / 05期

关键词：

D O I：

10.1016/S0002-9440(10)63005-2

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A novel presenilin binding protein, PBP, has recently been identified. PBP is localized to the particulate fraction of extracts of Alzheimer's disease brain but is found in the soluble fractions of brain from age matched normal controls. It is shown here that PBP is associated with neurofibrillary tangles in Alzheimer's disease brain. In addition, the expression of PBP increases the phosphorylation of tau in cultured cells. Therefore PBP may have a regulatory role in tau phosphorylation and in the genesis of neurofibrillary tangles.

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页码：1597 / 1602

页数：6

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