Uremic toxicity:: present state of the art

被引：218

作者：

Vanholder, R

Argilés, A

Baurmeister, U

Brunet, P

Clark, W

Cohen, G

De Deyn, PP

Deppisch, R

Descamps-Latscha, B

Henle, T

Jörres, A

Massy, ZA

Rodriguez, M

Stegmayr, B

Stenvinkel, P

Wratten, ML

机构：

[1] Ghent Univ Hosp, Dept Internal Med, Nephrol Sect, B-9000 Ghent, Belgium

[2] Inst Human Genet, IGH, CNRS, UPR 1142, Montpellier, France

[3] Membrana GmbH, Wuppertal, Germany

[4] Hop St Marguerite, Marseille, France

[5] Baxter Healthcare Corp, Lessines, Belgium

[6] Univ Vienna, Dept Med, Div Nephrol, Vienna, Austria

[7] Univ Antwerp, Middelheim Hosp, Dept Neurol, Lab Neurochem & Behav, Antwerp, Belgium

[8] Gambro Corp Res, Hechingen, Germany

[9] Hop Necker Enfants Malad, INSERM, U507, Paris, France

[10] Tech Univ Dresden, Inst Food Chem, D-8027 Dresden, Germany

[11] Humboldt Univ, Fac Med, UK Charite, Berlin, Germany

[12] Hop Necker Enfants Malad, INSERM, U507, Paris, France

[13] CH Beauvals, Div Nephrol, Paris, France

[14] Univ Hosp Reina Sofia, Res Inst, Cordoba, Spain

[15] Norrlands Univ Hosp, Med Clin, Umea, Sweden

[16] Huddinge Univ Hosp, Dept Nephrol, S-14186 Huddinge, Sweden

[17] Bellco SPA, Mirandola, Italy

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2001年 / 24卷 / 10期

关键词：

uremia; uremic toxins; low molecular weight proteins; AGE; PTH; AOPP; protein bound uremic solutes; P-cresol; CMPF; removal strategies;

D O I：

10.1177/039139880102401004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The uremic syndrome is a complex mixture of organ dysfunctions, which is attributed to the retention of a myriad of compounds that under normal condition are excreted by the healthy kidneys (uremic toxins). In the area of identification and characterization of uremic toxins and in the knowledge of their pathophysiologic importance, major steps forward have been made during recent years. The present article is a review of several of these steps, especially in the area of information about the compounds that could play a role in the development of cardiovascular complications. It is written by those members of the Uremic Toxins Group, which has been created by the European Society for Artificial Organs (ESAO). Each of the 16 authors has written a state of the art in his/her major area of interest.

引用

页码：695 / 725

页数：31

共 334 条

[1]

Abreo K, 1997, J AM SOC NEPHROL, V8, P935

[2]

AHMED MU, 1986, J BIOL CHEM, V261, P4889

[3] EXCESS PARATHYROID-HORMONE ADVERSELY AFFECTS LIPID-METABOLISM IN CHRONIC-RENAL-FAILURE [J].