Matrix metalloproteinases in reproductive endocrinology

被引:28
作者
Shah, BH [1 ]
Catt, KJ [1 ]
机构
[1] NICHHD, Sect Hormonal Regulat, Endocrinol & Reprod Res Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/j.tem.2004.01.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
One of the most common mechanisms for transactivation of epidermal growth factor receptor (EGF-R) by G protein-coupled receptors (GPCRs) is through the release of local EGF-like ligands from transmembrane precursors by the proteolytic action of matrix metalloproteinases (MMPs). These enzymes are crucial factors in the normal physiology of the reproductive system and also participate in neuroendocrine regulation through mediation of gonadotropin-releasing hormone (GnRH) action. Recent studies by Roelle et al. showed that GnRH-induced activation of the EGF-R and extracellular signal-regulated kinases 1 and 2 (ERK1/2) in pituitary gonadotrophs occurs through ectodomain shedding of heparin binding-EGF (HB-EGF) by MMP2 and MMP9, indicating a crucial role for MMPs in GnRH signaling.
引用
收藏
页码:47 / 49
页数:3
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