Genetic testing for atherosclerosis risk: Inevitability or pipe dream?

被引：11

作者：

Lanktree, Matthew

Hegele, Robert A. ^{[1
]}

机构：

[1] Univ Western Ontario, Vasc Biol Res Grp, Blackburn Cardiovasc Genet Lab, Robarts Res Inst, London, ON N6A 5K8, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2008年 / 24卷 / 11期

基金：

加拿大健康研究院;

关键词：

Atherosclerosis; Cardiovascular risk factors; Coronary artery disease; Genetic testing;

D O I：

10.1016/S0828-282X(08)70194-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Family history is a risk factor for coronary artery disease (CAD). However, defining this risk at the DNA level has been elusive. In 2007, four genome-wide association studies reported a strong association between CAD and a region on chromosome 9p21. The high-risk genotype Was identified in up to 30% of individuals, treating the Potential for a clinical genetic test to assist in the calculation of a patient's CAD risk. However, the reported effect size of the association is modest (OR of approximately 1.3). The present paper examines the feasibility of including DNA tests in CAD risk prediction algorithms. The greatest contribution from the 9p21 association is likely yet to come, as further studies identify the mechanistic basis for the association, possibly leading to additianal insights into the progression, prevention and treatment of CAD.

引用

页码：851 / 854

页数：4

共 34 条

[1] Relevance of genetics and genomics for prevention and treatment of cardiovascular disease - A scientific statement from the American Heart Association Council on epidemiology and prevention, the stroke council, and the functional genomics and translational biology interdisciplinary working group [J].

Arnett, Donna K. ;

Baird, Alison E. ;

Barkley, Ruth A. ;

Basson, Craig T. ;

Boerwinkle, Eric ;

Ganesh, Santhi K. ;

Herrington, David M. ;

Hong, Yuling ;

Jaquish, Cashell ;

McDermott, Deborah A. ;

O'Donnell, Christopher J. .

CIRCULATION, 2007, 115 (22) :2878-2901

[2] Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the Prospective Cardiovascular Munster (PROCAM) study [J].

Assmann, G ;

Cullen, P ;

Schulte, H .

CIRCULATION, 2002, 105 (03) :310-315

[3] A comprehensive linkage analysis for myocardial infarction and its related risk factors [J].

Broeckel, U ;

Hengstenberg, C ;

Mayer, B ;

Holmer, S ;

Martin, LJ ;

Comuzzie, AG ;

Blangero, J ;

Nürnberg, P ;

Reis, A ;

Riegger, GAJ ;

Jacob, HJ ;

Schunkert, H .

NATURE GENETICS, 2002, 30 (02) :210-214

[4] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[5] The need for reorientation toward cost-effective prediction:: Comments on 'Evaluating the added predictive ability of a new marker:: From area under the ROC curve to reclassification and beyond' by Pencina et al., Statistics in Medicine [J].

Chi, Yueh-Yun ;

Zhou, Xiao-Hua .

STATISTICS IN MEDICINE, 2008, 27 (02) :182-184

[6] A comparison of the PROCAM and Framingham point-scoring systems for estimation of individual risk of coronary heart disease in the Second Northwick Park Heart Study [J].

Cooper, JA ;

Miller, GJ ;

Humphries, SE .

ATHEROSCLEROSIS, 2005, 181 (01) :93-100

[7] Validation of the Framingham Coronary Heart Disease prediction scores - Results of a multiple ethnic groups investigation [J].

D'Agostino, RB ;

Grundy, S ;

Sullivan, LM ;

Wilson, P .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (02) :180-187

[8] The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk [J].

Drenos, F. ;

Whittaker, J. C. ;

Humphries, S. E. .

ANNALS OF HUMAN GENETICS, 2007, 71 :611-619

[9] Finding genes that underlie complex traits [J].

Glazier, AM ;

Nadeau, JH ;

Aitman, TJ .

SCIENCE, 2002, 298 (5602) :2345-2349

[10] Major risk factors as antecedents of fatal and nonfatal coronary heart disease events [J].

Greenland, P ;

Knoll, MD ;

Stamler, J ;

Neaton, JD ;

Dyer, AR ;

Garside, DB ;

Wilson, PW .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (07) :891-897

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