Microbubble-Mediated Oxygen Delivery to Hypoxic Tissues as a New Therapeutic Device

被引：20

作者：

Bisazza, Agnese ^{[1
]}

Giustetto, Pierangela ^{[2
]}

Rolfo, Alessandro ^{[3
]}

Caniggia, Isabella ^{[3
]}

Balbis, Sonia ^{[2
]}

Guiot, Caterina ^{[4
]}

Cavalli, Roberta ^{[1
]}

机构：

[1] Univ Turin, Dept Drug Sci & Technol, Turin, Italy

[2] Univ Turin, Dept Neurosci, Turin, Italy

[3] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Obstet & Gynaecol, Toronto, ON, Canada

[4] Univ Turin, CCNISM, I-10124 Turin, Italy

来源：

2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8 | 2008年

关键词：

microbubble; oxygen; release; delivery;

D O I：

10.1109/IEMBS.2008.4649599

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Chitosan-coated oxygen microbubbles of average diameter 2.5 mu m, narrow size distribution and spherical shape were prepared. A core-shell structure was evidenced by fluorescence microscopy using fluorescent microbubbles. Such microbubbles can be a therapeutic device for vehiculating oxygen to hypoxic tissues, provided they show proper permeability and diffusivity properties and are non-toxic. Our study proves that oxygen is efficiently delivered both in 'in vitro' and 'in vivo' preparations, and can be conveniently metabolized reversing the cellular hypoxic response. Moreover, toxic effects were investigated in human blood and in cultured cells and no evidence for them was found.

引用

页码：2067 / +

页数：2

共 12 条

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[2]

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3 [J].