A practical ruthenium-catalyzed cleavage of the allyl protecting group in amides, lactams, imides, and congeners

被引：61

作者：

Alcaide, B ^{[1
]}

Almendros, P

Alonso, JM

机构：

[1] Univ Complutense Madrid, Dept Quim Organ 1, E-28040 Madrid, Spain

[2] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2006年 / 12卷 / 10期

关键词：

amides; cleavage reactions; lactams; protecting groups; ruthenium;

D O I：

10.1002/chem.200501227

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient methodology for the deprotection of N-allylic amide-like moieties was developed. The first examples accounting for the ruthenium-catalyzed deallylation of amides, lactams, imides, pyrazolidones, hydantoins, and oxazolidinones have been achieved by the sequential use of Grubbs carbene (isomerization step) and RUCl3 (oxidation step). A variety of substrates, including enantio-pure multifunctional beta- and gamma-lactams, can be employed.

引用

页码：2874 / 2879

页数：6

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