Inflammatory markers and coronary artery disease

被引:51
作者
Fichtlscherer, S [1 ]
Heeschen, C [1 ]
Zeiher, AM [1 ]
机构
[1] Goethe Univ Frankfurt, Dept Cardiol, D-60590 Frankfurt, Germany
关键词
D O I
10.1016/j.coph.2004.01.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In the past decade, the important role of inflammatory processes in the development and progression of atherosclerosis has been clearly established. Over the past two years, different circulating (inflammatory) biomarkers indicating the instability of atherosclerotic plaques have been identified. These new markers do not only serve as diagnostic tools for the identification of patients with unstable angina or acute myocardial infarction but also help us to identify high-risk patients. As a result, different markers are used clinically for risk stratification in stable coronary artery disease as well as in acute coronary syndromes.
引用
收藏
页码:124 / 131
页数:8
相关论文
共 79 条
[1]   Nitric oxide is a physiological substrate for mammalian peroxidases [J].
Abu-Soud, HM ;
Hazen, SL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :37524-37532
[2]   Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study [J].
Albert, MA ;
Danielson, E ;
Rifai, N ;
Ridker, PM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01) :64-70
[3]   Plasma concentration of C-reactive protein and the calculated Framingham Coronary Heart Disease Risk Score [J].
Albert, MA ;
Glynn, RJ ;
Ridker, PM .
CIRCULATION, 2003, 108 (02) :161-165
[4]   Alcohol consumption and plasma concentration of C-reactive protein [J].
Albert, MA ;
Glynn, RJ ;
Ridker, PM .
CIRCULATION, 2003, 107 (03) :443-447
[5]   Elevation of serum levels of the anti-inflammatory cytokine interleukin-10 and decreased risk of coronary events in patients with unstable angina [J].
Anguera, I ;
Miranda-Guardiola, F ;
Bosch, X ;
Filella, X ;
Sitges, M ;
Marín, J ;
Betriu, A ;
Sanz, G .
AMERICAN HEART JOURNAL, 2002, 144 (05) :811-817
[6]   Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes [J].
Antman, EM ;
Tanasijevic, MJ ;
Thompson, B ;
Schactman, M ;
McCabe, CH ;
Cannon, CP ;
Fischer, GA ;
Fung, AY ;
Thompson, C ;
Wybenga, D ;
Braunwald, E .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (18) :1342-1349
[7]   ENDOGENOUS INTERLEUKIN-10 PREVENTS APOPTOSIS IN MACROPHAGES DURING SALMONELLA INFECTION [J].
ARAI, T ;
HIROMATSU, K ;
NISHIMURA, H ;
KIMURA, Y ;
KOBAYASHI, N ;
ISHIDA, H ;
NIMURA, Y ;
YOSHIKAI, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 213 (02) :600-607
[8]   Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes [J].
Baldus, S ;
Heeschen, C ;
Meinertz, T ;
Zeiher, AM ;
Eiserich, JP ;
Münzel, T ;
Simoons, ML ;
Hamm, CW .
CIRCULATION, 2003, 108 (12) :1440-1445
[9]   Pregnancy-associated plasma protein a as a marker of acute coronary syndromes [J].
Bayes-Genis, A ;
Conover, CA ;
Overgaard, MT ;
Bailey, KR ;
Christiansen, M ;
Holmes, DR ;
Virmani, R ;
Oxvig, C ;
Schwartz, RS .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (14) :1022-1029
[10]   ELEVATION OF C-REACTIVE PROTEIN IN ACTIVE CORONARY-ARTERY DISEASE [J].
BERK, BC ;
WEINTRAUB, WS ;
ALEXANDER, RW .
AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (03) :168-172