Thiol-independent DNA cleavage by a leinamycin degradation product

被引：21

作者：

Asai, A ^{[1
]}

Saito, H ^{[1
]}

Saitoh, Y ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,NAGAIZUMI,SHIZUOKA 411,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1997年 / 5卷 / 04期

关键词：

D O I：

10.1016/S0968-0896(97)00015-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To understand the mechanism of action of a novel antitumor antibiotic leinamycin (1) which induces single-strand scission of DNA in the presence of thiol, the reaction of 1 with thiol in aqueous conditions was investigated. Two major degradation products were obtained from 1 in the presence of thiol. 2 was an inactive product, while 3 caused DNA cleavage in the absence of thiol. The DNA-cleaving activity of their synthetic derivatives indicates that the DNA alkylation and subsequent strand scission by leinamycin require the conversion of leinamycin to an electrophilic episulfonium species. (C) 1997 Elsevier Science Ltd.

引用

页码：723 / 729

页数：7

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