Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 angstrom resolution

被引：201

作者：

Rasmussen, H

Kastrup, JS

Nielsen, JN

Nielsen, JM

Nielsen, PE

机构：

[1] ROYAL DANISH SCH PHARM, DEPT MED CHEM, DK-2100 COPENHAGEN 0, DENMARK

[2] UNIV COPENHAGEN, PANUM INST,DEPT MED BIOCHEM & GENET, CTR BIOMOL RECOGNIT,BIOCHEM LAB B, DK-2200 COPENHAGEN N, DENMARK

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 02期

关键词：

D O I：

10.1038/nsb0297-98

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of a PNA duplex reveals both a right- and a left-handed helix in the unit cell. The helices are wide (28 Angstrom), large pitched (18 bp) with the base pairs perpendicular to the helix axis, thereby demonstrating that PNA besides adapting to oligonucleotide partners also has a unique structure by itself.

引用

页码：98 / 101

页数：4

共 21 条

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