Glial Influence on the Blood Brain Barrier

被引：422

作者：

Alvarez, Jorge Ivan ^{[1
]}

Katayama, Takahiro ^{[1
]}

Prat, Alexandre ^{[1
]}

机构：

[1] CRCHUM, Neuroimmunol Unit, Montreal, PQ, Canada

来源：

GLIA | 2013年 / 61卷 / 12期

关键词：

astrocyte; BBB; glial; astrogliosis; multiple sclerosis; CENTRAL-NERVOUS-SYSTEM; NF-KAPPA-B; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ENDOTHELIAL-CELL PERMEABILITY; POTASSIUM CHANNEL KIR4.1; CULTURED RAT ASTROCYTES; MULTIPLE-SCLEROSIS; TIGHT JUNCTIONS; GENE-EXPRESSION; NEUROMYELITIS-OPTICA;

D O I：

10.1002/glia.22575

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB and control of their barrier phenotype resides on astrocytes and pericytes. Interactions between these cells and the endothelium promote and maintain many of the physiological and metabolic characteristics that are unique to the BBB. In this review we describe recent findings related to the involvement of astroglial cells, including radial glial cells, in the induction of barrier properties during embryogenesis and adulthood. In addition, we describe changes that occur in astrocytes and endothelial cells during injury and inflammation with a particular emphasis on alterations of the BBB phenotype.

引用

页码：1939 / 1958

页数：20

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