Cytosolic phospholipase A2α reigns supreme in arthritis and bone resorption

被引：55

作者：

Bonventre, JV

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Renal,Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, MIT, Div Hlth Sci & Technol, Boston, MA 02115 USA

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 03期

关键词：

D O I：

10.1016/j.it.2004.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The superfamily of phospholipase A(2) (PLA(2)alpha) enzymes implicated in arachidonic acid release has grown in number with members having different structural characteristics, substrate specificity, calcium dependency and cellular localization. Despite this growing complexity and multiple attacks on its position as the reigning monarch of this superfamilly, the 85 kDa cytosolic PLA(2)alpha continues to rule supreme, having a primary role in many pathophysiological conditions. The most recent addition to the list of accolades of this enzyme is reflected in two important papers in which the use of the cytosolic cPLA(2)alpha (cPLA(2)alpha)-null mouse demonstrates crucial roles of this enzyme in collagen-induced arthritis and prostaglandin E-2 (PGE(2))-mediated bone resorption associated with inflammation.

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页码：116 / 119

页数：4

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