Chemocontrolled reduction of aromatic alpha-ketoesters by NaBH4: Selective synthesis of alpha-hydroxy esters or 1,2-diols

被引：29

作者：

Dalla, V

Cotelle, P

Catteau, JP

机构：

[1] Lab. Chim. Organique/M., Associé au CNRS, Univ. des Sciences et Technologies

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(97)00154-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-hydroxyesters 5a-g or diols 6a-g have been obtained in high yields by reduction of aromatic alpha-ketoesters 4 once or twice respectively by using NaBH4 as the reducer under suitable conditions. The use of a solvent that does not interact with the reagent allowed the double reduction to occur with only a slight excess of borohydride in very mild conditions. (C) 1997 Elsevier Science Ltd.

引用

页码：1577 / 1580

页数：4

共 20 条

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