Effects of arginine, L-alanyl-L-glutamine or taurine on neutrophil (PMN) free amino acid profiles and immune functions in vitro

被引：42

作者：

Mühling, J

Fuchs, M

Fleck, C

Sablotzki, A

Krüll, M

Dehne, MG

Gonter, J

Weiss, S

Engel, J

Hempelmann, G

机构：

[1] Univ Giessen, Dept Anaesthesiol & Intens Care Med, D-35385 Giessen, Germany

[2] Herbert Knauer GmbH, Berlin, Germany

[3] Univ Jena, Inst Pharmacol & Toxicol, D-6900 Jena, Germany

[4] Univ Halle Wittenberg, Clin Anaesthesiol, Halle An Der Saale, Germany

[5] Univ Halle Wittenberg, Clin Intens Care Med, Halle An Der Saale, Germany

[6] Humboldt Univ, Dept Internal Med Infect Dis, Charite, Sch Med, Berlin, Germany

来源：

AMINO ACIDS | 2002年 / 22卷 / 01期

关键词：

amino acids; arginine; L-alanyl-L-glutamine; taurine; neutrophil; immune function;

D O I：

10.1007/s726-002-8200-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The objective of this study was to determine the effects of arginine, L-alanyl-L-glutamine (Ala-Gln) or taurine on polymorphonuclear leucocyte (PMN) free amino acid profiles, superoxide anion (O-2(-)) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase activity (MPO). Arginine led to significant increases in PMN arginine, ornithine, citrulline, aspartate, glutamate and alanine concentrations as well as increased H2O2-generation and MPO activity while O-2(-)-formation was decreased. Ala-Gln caused significant increases in PMN free glutamine, alanine, asparagine, aspartate, glutamate, ornithine, arginine, serine and glycine concentrations and increased PMN immune functions. Taurine significantly increased PMN free taurine profiles, reduced PMN neutral amino acid content and decreased H2O2- and O-2(-)-formation while MPO was increased. Altogether, the pharmacological regimens which enhance the supply of arginine, Ala-Gln or taurine in whole blood significantly affect PMN "susceptible free amino acid pool". This may be one of the determinants in PMN nutrition considerably influencing PMN immune functions.

引用

页码：39 / 53

页数：15

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